Gray JC, Weston R, Owens C, Canete A, Gambart M, De Wilde B, Nysom K, van Eijkelenburg N, Ladenstein R, Castellano A, Gerber NU, Marshall LV, Barone G, Rubio-San-Simon A, Ng A, Vaidya S, Gallego S, Makin G, Burke GAA, McCarthy A, Murphy D, Zwaan CM, López-Almaraz R, Jannier S, Thebaud E, Corradini N, Yeomanson D, Howell L, Tweddle DA, Elliott M, Hobin D, Valteau-Couanet D, Schleiermacher G, Chastagner P, Defachelles AS, Brichard B, George S, Chesler L, Laidler J, Firth C, Holt G, Moroz V, Pearson ADJ, Gates S, Wheatley K, Kearns P, Moreno L.
Dinutuximab Beta Added to Temozolomide-Based Chemotherapy for Children With Relapsed and Refractory Neuroblastoma: Results of the ITCC-SIOPEN BEACON Immuno Phase II Trial.
J Clin Oncol. 2026 Jan 20;44(3):176-187.
DOI: 10.1200/JCO-25-01868
IF: 43.4
RESEARCH GROUPS
Childhood Cancer and Blood Disorders
Number of publications
% Q1
% D1
% Leadership
% Female Leadership
CROWN (2021-2025)
HCP10% (2021-2025)
% Open access
% International Collaboration
Highly cited papers / HCP 1% (2021-2025)
Publications in high-IF journals with high Altmetric scores
Number of Ongoing Projectes (total)
International ongoing projects
Number of New projects (total)
International new projects
Number of Active clinical Trials
Number of New Clinical Trials
Number of Theses
CORE/MISSIONS
- AI, Data, Imaging & Digital Health
- Innovative & Advanced Therapies
- Rare Diseases
PROGRAMS
TEAM
Group Leader
Lucas Moreno Martín Retortillo
Principal Investigator (PI)
Lucas Moreno MD PhD, Miguel F Segura PhD, Josep Roma PhD, Mar Mañú PhD, Aroa Soriano PhD, Cristina Diaz de Heredia MD, Pablo Velasco MD
Researchers
Maria J Pérez PhD, Khloud Elsharawy PhD, Amira Idrizovic PhD, Patricia Zarzosa PhD, Isabel de Rojas PhD, Guillem Pons PhD, Maria R Pérez-Torres MD, Maria P Pérez MD, Laura Murillo, Lorena Valero MD, Gabriela Guillen MD PhD, Raquel Hladun MD, Melissa Panesso MD, Anna LLort MD PhD, Thais Murciano MD, Mariona Morell MD, Luis Gros MD, Amalia Varo MD, Laura Murillo MD, Marina Bonfill MD, Sofia Alperi MD, Ohiane Bedialauneta MD, Andrés Morgenstern MD.
PhD Students
Lia Garcia, Julia Sansa, Adrià Molero, Marta Miera, Maria Gallego, Anna Collado, Sara I Reidel, Gal·la Farreny, Andrea Vilaplana.
Lab Technicians
Maria Jesús Rodriguez, Juan Manuel López
SELECTED PUBLICATIONS
Castelli S, Schulze F, Thole-Kliesch TM, Astrahantseff K, Barone G, Beck-Popovic M, Berlanga P, Corbacioglu S, Fischer M, Gambart M, George SL, Chesler L, Gray JC, Hero B, Künkele A, Flaadt T, Lang P, Lode HN, Molenaar JJ, Schleiermacher G, Rosswog C, Moreno L, Owens C, Rubio-San-Simón A, Schulte JH, Simon T, Tweddle DA, Deubzer HE, Eggert A
New Drug Development, Immunotherapy and Relapse Groups. Current treatment strategies for first relapse of high-risk neuroblastoma.
Eur J Cancer. 2026 Mar 11;236:116254
DOI: 10.1016/j.ejca.2026.116254
IF: 7.1
Chatzimatthaiou, Sotiroula ;Bonifazi, Fedele ;Gimbert, Anna C. ;Colombatti, Raffaella ;Cremonesi, Francesco ;Glenthoj, Andreas ;Mezzalira, Elisabetta ;Stephanou, Coralea ;Traeger-synodinos, Jan ;Antic, Darko ;Durmaz, Burak ;Gavriilaki, Eleni ;Inusa, Baba ;Landi, Annalisa ;Pellegrini, Mariangela ;Basile, Francesca ;Muth, Stephanie ;Cario, Holger ;Katsantoni, Eleni ;Ruhluel, Dilem ;Lederer, Carsten Werner ;Manu-pereira, Maria Del Mar ;Kountouris, Petros
HELIOS Action: Advancing research, education, and equity in hemoglobinopathies across Europe and beyond
HemaSphere vol. 9,12 e70258. 8 Dec. 2025
DOI: 10.1002/hem3.70258
IF: 14.6
Río P, Zubicaray J, Navarro S, Gálvez E, Sánchez-Domínguez R, Nicoletti E, Sebastián E, Rothe M, Pujol R, Bogliolo M, John-Neek P, Bastone AL, Schambach A, Wang W, Schmidt M, Larcher L, Segovia JC, Yáñez RM, Alberquilla O, Díez B, Fernández-García M, García-García L, Ramírez M, Galy A, Lefrere F, Cavazzana M, Leblanc T, García de Andoin N, López-Almaraz R, Catalá A, Barquinero J, Rodríguez-Perales S, Rao G, Surrallés J, Soulier J, Díaz-de-Heredia C, Schwartz JD, Sevilla J, Bueren JA;
FANCOLEN-1 gene therapy investigators. Haematopoietic gene therapy of non-conditioned patients with Fanconi anaemia-A: results from open-label phase 1/2 (FANCOLEN-1) and long-term clinical trials.
Lancet. 2025 Dec 21;404(10471):2584-2592.
DOI: 10.1016/S0140-6736(24)01880-4.
IF: 88.5
Carceller F, Bautista F, Van Tinteren H, Castañeda A, Surun A, Wasti A, Revon-Rivière G, Bergamaschi L, Cortés M, Hladun-Álvaro R, Jiménez I, Giraud C, Millen G, Campbell-Hewson Q, Juan-Ribelles A, Van der Lugt J, Amoroso L, Bertorello N, Hargrave D, Vega-Piris L, Fagioli F, Haupt R, Zwaan CM, Cañete A, Morland B, Ceraulo A, Casanova M, Verschuur A, André N, Aerts I, Doz F, Pearson ADJ, Marshall LV, Vassal G, Kearns P, Geoerger B, Moreno L.
Prognostic factors of early mortality in children and adolescents with relapsed/refractory solid tumors participating in dose-finding trials in the targeted and immune therapies era: An ITCC study.
Eur J Cancer. 2025 Sep 9;227:115627.
DOI: 10.1016/j.ejca.2025.115627
IF: 7.1
SELECTED PROJECTS
MONALISA: A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis
Principal Investigator: Lucas Moreno (VHIR)
Agency: HORIZON-MISS-2023-CANCER-01-03
Funding: VHIR 84.000,00€
Period: 2022-2028
SEHOP-PENCIL - National Strategy for the Implementation of Personalised Medicine in Children and Adolescents with Cancer
Principal Investigator: Lucas Moreno
Agency: ISCIII
Funding: 1,025,179.10 €
Period: 2022-2026
Comprehensive methodological and operational approach to clinical trials in rare and ultra-rare diseases
Principal Investigator: M. Mar Mañu
Agency: Horizon Europe
Funding: 8,500,000.00 €
Period: 2025-2029
Advanced development of innovative Therapies against childhood sarcomas: Refinement of pharmacological blockade of Hedgehog pathway co-receptors
Principal Investigator: Josep Roma
Agency: ISCIII
Funding: 190,000.00 €
Period: 2025-2027
COMIK 2.0: Integration of a genomic and functional screening platform for paediatric precision oncology
Principal Investigator: Lucas Moreno
Agency: ISCIII
Funding: 124,170.00 €
Period: 2022-2026
PATENTS
Compounds for use in preventing or treating cancer
Priority Number: PCT/EP2019/067557
Priority Date: 29/06/2018
Applicants: VHIR/LEITAT/SELABTEC
Peptides for the treatment of cancer and/or metastasis.
Priority Number: EP19383084.1
Priority Date: 05/12/2019
Applicants: VHIR / BCN peptides
Nanovesicles and its use for nucleic acid delivery.
Priority Number: PCT/EP2020/063195
Priority Date: 12/05/2020
Applicants: VHIR / CSIC / CIBER
A pharmaceutical combination for the treatment of cancer
Priority Number: WO2018EP62554
Priority Date: 09/08/2017
Applicants: Ability Pharmaceuticals S.L
DISSEMINATION ACTIVITIES
Scientific talk and laboratory visit
Place: VHIR
Date: 16/04/2025
Brief: Outreach activity with children aged 12–15 from the CRAE Minerva center, consisting of a visit to the Vall d’Hebron Research Institute (VHIR) and an introductory talk on the main research lines of our group.
Scientific talk
Place: UB
Date: 25/04/2026
Brief: Scientific talk for general public.
Fira del Somnis
Place: Balaguer, Lleida
Date: 04/05/2026
Brief: Participants engaged in interactive activities focused on identifying common laboratory elements, understanding food oxidation processes, and constructing DNA models using candy.
EscoLab visit
Place: VHIR
Date: 15/10/2025
Brief: For students from a technical laboratory training institute.
Clotxa Solidaria
Place: Mora d'Ebre
Date: 08/11/2025
Brief: Interactive activities focused on identifying common laboratory elements, understanding food oxidation processes, and constructing DNA models using candy