Izagirre A, Sarasqueta C, Flores-Arriaga J, Aso MC, Perez M, Tack J, Huang IH, Sperber AD, Palsson OS, Bangdiwala SI, D'Amato M, Lanas A, Lobo B, Alonso-Cotoner C, Santos J, Bujanda L
Worldwide Prevalence and Description of Cyclic Vomiting Syndrome According to the Results of the Rome Foundation Global Epidemiology Study
Am J Gastroenterol. 2025 May 1;120(5):1108-1115
DOI: 10.14309/ajg.0000000000003105.
IF: 8.5
RESEARCH GROUPS
Physiology and Pathophysiology of the Digestive Tract
46
Number of publications
67.39
%
% Q1
23.91
%
% D1
67.39
%
% Leadership
32.26
%
% Female Leadership
2.45
CROWN (2021-2025)
22.66
%
HCP10% (2021-2025)
69.57
%
% Open access
52.17
%
% International Collaboration
7
Highly cited papers / HCP 1% (2021-2025)
2
Publications in high-IF journals with high Altmetric scores
7
Number of Ongoing Projectes (total)
2
International ongoing projects
3
Number of New projects (total)
0
International new projects
8
Number of Active clinical Trials
3
Number of New Clinical Trials
0
Number of Theses
The group leads a translational, interdisciplinary program on microbiota–host interactions, inflammatory and functional gastrointestinal disorders, pancreatic disease and digestive motility. Using multi-omic, mechanistic and clinical approaches, it has clarified links between diet, microbiota and intestinal inflammation, identifying microbial mediators in IBD and epithelial changes in microscopic colitis. It has also advanced gut–brain interaction disorders through trials and physiological studies, proving the efficacy of thoraco-abdominal biofeedback for distension and strengthening digital care in IBS and functional dyspepsia. Research extends to systemic immune-mediated diseases such as systemic sclerosis, eosinophilic GI disorders and celiac disease, combining scientific excellence with clinical innovation and international collaboration.
CORE/MISSIONS
- Aging
PROGRAMS
- Woman, Gender & Diversity Perspective in Health Research
TEAM
Group Leader
Francisco Javier Santos Vicente
Principal Investigator (PI)
M Carmen Alonso Cotoner, Luís G. Alcalá González, Natalia Borruel Sainz, Danila Guagnozzi, Beatriz Lobo Álvarez, Carolina Malagelada Prats, Jorge Serra Pueyo
Researchers
Caudia Barber Caselles, Virginia Robles Alonso, Claudia Herrera De Guise, Ana María González Castro, Erika Zodda, Raquel Ibañez Ferrer
PhD Students
Ariadna Aguilar Cayuelas, Luis Fernando Mayorga Ayala, Ernesto Lastiri González, Elena Céspedes Martínez, Lara Aguilera Castro, Xavier Serra Ruiz, Stephanie Tasayco Huamán, Joel Víctor Flores Arriaga
SELECTED PUBLICATIONS
Rodiño-Janeiro BK, Khannous-Lleiffe O, Pigrau M, Willis JR, Salvo-Romero E, Nieto A, Expósito E, Fortea M, Pardo-Camacho C, Albert-Bayo M, González-Castro AM, Guagnozzi D, Martínez C, Lobo B, Vicario M, Santos J, Gabaldón T, Alonso-Cotoner C
Acute stress triggers sex-dependent rapid alterations in the human small intestine microbiota composition.
Front Microbiol. 2025 Jan 15;15:1441126.
DOI: 10.3389/fmicb.2024.144112
IF: 4.6
Malagelada C, Keller J, Sifrim D, Serra J, Tack J, Mulak A, Stengel A, Aguilar A, Drewes AM, Josefsson A, Bonaz B, Dumitrascu D, Keszthelyi D, Barba E, Carbone F, Zerbib F, Marchegiani G, Hauser G, Gourcerol G, Tornblom H, et al
European Guideline on Chronic Nausea and Vomiting-A UEG and ESNM Consensus for Clinical Management.
United European Gastroenterol J. 2025 Apr;13(3):427-471.
DOI: 10.1002/ueg2.12711.
IF: 5.8
Cespedes-Martinez E, Robles-Alonso V, Serra-Ruiz X, Herrera-De Guise C, Mayorga-Ayala L, Garcia-Garcia S, Larrosa-Garcia M, Casellas F, Borruel N
Dashboard-Guided Anti-TNF Induction: An Effective Strategy to Minimize Immunogenicity While Avoiding Immunomodulators-A Single-Center Cohort Study.
Crohns Colitis 360. 2025 Jun 27;7(3):otaf023.
DOI: 10.1093/crocol/otaf023
IF: 8.7
Sara Villasante, Nair Fernandes, Marc Perez, Miguel Angel Cordobés, Carmen Galiana, Carolina Gonzalez, Fabio Ausania, Jimmy Harold, Nils Jimmy, Elena Ramirez, Silvia Salord, María Sorribas, Stephanie Tasayco, Concepción Gomez-Gavara, Laia Blanco, Piero Alberti, Ramón Charco, Elizabeth Pando
Prediction of Severe Acute Pancreatitis at a Very Early Stage from an Integrative Multi-Omics Gut Microbiota and Metabolite Signature
Annals of Surgery. January 2025
DOI: 10.1097/SLA.0000000000006579
IF: 6.5
SELECTED PROJECTS
Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in IRritable bowel syndrome In Europe.
Principal Investigator: Santos Vicente, Fco Javie
Agency: EUROPEAN COMMISSION
Funding: 1,148,684.84 € (6,000,000 € assigned)
Period: 01/01/2020-31/05/2025
The Health Outcomes Observatory project
Principal Investigator: Natalia Borruel
Agency: EUROPEAN COMMISSION
Funding: 22,741,031 €
Period: 01/10/2020 - 31/03-2026
Development of new oral biologics for Inflammatory Bowel Disease
Principal Investigator: Santos Vicente, Fco Javier
Agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 656,675.17 € (Total) 218,513.00 € (VHIR)
Period: 01/12/2023 - 30/11/2026
CFTR down regulation enhances pancreatic carcinogenesis and promotes cancer invasion and metastasis
Principal Investigator: Tasayco Huaman, Stephanie
Agency: Cystic Fibrosis Foundation
Funding: 300.565,29 €
Period: 01/05/2022 - 31/03/2026
New tool based on Artificial Intelligence and Biomarkers for early non-invasive diagnosis of Pancreatic Cancer - AI-Early PanC
Principal Investigator: Tasayco Huaman, Stephanie
Agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 293,321.00 €
Period: 01/10/2023 - 31/08/2026
PATENTS
DISSEMINATION ACTIVITIES
Talk 'Disfunció cervell-intestinal en les malalties mentals i no mentals'.
Place: Centre Cívic Vil·la Urània.
Date: 11/06/2025
Brief: Professionals from different specialities at Vall d'Hebron University Hospital will debate the relationship between the dysfunction of the brain-gut-microbiota connection and the origin of some very common diseases such as Irritable Bowel Syndrome, anxiety and depression, and fibromyalgia and chronic fatigue syndrome, which often overlap in many patients.
XVI Congreso de la Sociedad Española de Microbiota, Probióticos y Prebióticos (SEMiPyP)
Place: Málaga
Date: February 2025
Brief: Psychobiotics: a new approach to stress management
Microbiota Aplicada: avances científicos para transformar la medicina de precisión
Place: Gaceta Médica
Date: 09/04/2025
Brief: Javier Santos outlines to Gaceta Médica the key points to be covered at the event
Interview Dr. Jordi Serra
Place: TV3 "Tot es mou"
Date: 18/09/2025
Brief: Interview about digestive health.
Interview Dr. Carolina Malagelada
Place: RAC1 "Versió RAC1"
Date: 29/12/2025
Brief: Interview about digestive health.
