Mayorga L, Noguera Segura A, Campderros L, Pons-Tarin M, Soler Z, Vega-Abellaneda S, Serrano-Gomez G, Herrera-deGuise C, Robles-Alonso V, Borruel N, Manichanh C.
Distinct microbial mediators link diet to inflammation in Crohn's disease and ulcerative colitis
Gut, 2025-2026
DOI: 10.1136/gutjnl-2025-337480
IF: 26.2
RESEARCH GROUPS
Microbiome Research
4
Number of publications
100.00
%
% Q1
50.00
%
% D1
100.00
%
% Leadership
100.00
%
% Female Leadership
1.36
CROWN (2021-2025)
22.58
%
HCP10% (2021-2025)
100.00
%
% Open access
50.00
%
% International Collaboration
0
Highly cited papers / HCP 1% (2021-2025)
0
Publications in high-IF journals with high Altmetric scores
7
Number of Ongoing Projectes (total)
0
International ongoing projects
3
Number of New projects (total)
0
International new projects
4
Number of Active clinical Trials
0
Number of New Clinical Trials
2
Number of Theses
During 2025, the group advanced research on the interplay between diet, lifestyle, and host factors in shaping the gut microbiome and its role in IBD. Using population-based cohorts and multi-omics integration, we identified microbial signatures linked to inflammation and disease, and characterized early microbiome alterations in individuals at risk of IBD, including first-degree relatives. We demonstrated that these individuals exhibit transitional microbiome states with distinct taxonomic and virulence features, enabling risk stratification. The group also implemented innovative citizen science approaches to collect large-scale dietary and lifestyle data, strengthening real-world evidence generation. These efforts resulted in several peer-reviewed publications and reinforced leadership in multidisciplinary, data-driven microbiome research.
CORE/MISSIONS
PROGRAMS
TEAM
Group Leader
Chaysavanh Manichanh
Principal Investigator (PI)
Chaysavanh Manichanh
Researchers
Laura Campderros
PhD Students
Zaida Soler, Gerard Serrano, Luis Mayorga, Sara Vega, Arnau Noguera
Lab Technicians
Marc Pons
SELECTED PUBLICATIONS
Vega-Abellaneda S, Román E, Soler Z, Ortiz MÀ, Rossi G, Biagini L, Sánchez E, Pons-Tarin M, Laghi L, Mengucci C, Kaur N, Poca M, Cuyàs B, Serrano-Gomez G, Alvarado E, Manichanh C, Soriano G.
A Metagenomics Approach to Frailty in Patients With Cirrhosis Undergoing a Multifactorial Intervention
Liver Int, 2025
DOI: 10.1111/liv.70418
IF: 5.2
Soler Z, Serrano-Gómez G, Pons-Tarín M, Vega-Abellaneda S, Xie Z, Manjón I, Cognard C, Varela E, Yañez F, Noguera-Segura A, Roca-Bosch M, Manichanh C.
A contributory citizen science project reveals the impact of dietary keys to microbiome health in Spain
NPJ Biofilms Microbiomes, 2025
DOI: 10.1038/s41522-025-00769-9
IF: 9.2
Serrano-Gómez G, Yañez F, Soler Z, Pons-Tarin M, Mayorga L, Herrera-deGuise C, Borruel N, Rodriguez-Sinovas A, Consegal M, Manjón I, Vega-Abellaneda S, Manichanh C.
Microbiome multi-omics analysis reveals novel biomarkers and mechanisms linked with CD etiopathology
Biomark Research, 2025
DOI: 10.1186/s40364-025-00802-1
IF: 11.5
Del Barco E, Molano LG, Vargas M, Miserachs M, Puerto L, Garrido-Giménez C, Soler Z, Muñoz B, Pratcorona L, Rimbaut S, Vidal M, Dalmau M, Casellas A, Carreras E, Manichanh C, Goya M.
The Effect of Probiotics on Preterm Birth Rates in Pregnant Women After a Threatened Preterm Birth Episode (The PROPEV Trial)
Biomedicines, 2025
DOI: 10.3390/biomedicines13051141
IF: 3.9
SELECTED PROJECTS
Modulation of the Gut Microbiota and Immune System
Principal Investigator: Chaysavanh Manichanh
Agency: MICINN
Funding: 237,500 €
Period: 2024-2028
Use of gut mucosal explants to study the effect of a synbiotic on the host immune response
Principal Investigator: Chaysavanh Manichanh
Agency: Danone
Funding: 145,200 €
Period: 2024-2026
PATENTS
DISSEMINATION ACTIVITIES
Citizen Science
Place: https://manichanh.vhir.org/
Date: 2025
Brief: POP Study: dietary habits and gut microbiome of the Spanish population
