Adrien Krug, Lena M. Ernst, Rana Mhaidly, Joana Ramis, Muriel F. Gusta, Neus G. Bastus, Adriana Martinez-Turtos, Marie Tosolini, Léa Di Mascio, Gamze Tari, Laurent Boyer, Philippe Gaulard, François Lemonnier, Jean-Ehrland Ricci, Els Verhoeyen, Victor Puntes
Scavenging Reactive Oxygen Species by Cerium Oxide Nanoparticles Prevents Death in a Peripheral T Cell Lymphoma Preclinical Mouse Model
ACS nano, 19, 18644-18660 (2025)
DOI: 10.1021/acsnano.5c02860
IF: 16.1
RESEARCH GROUPS
Pharmacokinetic Nanoparticles
7
Number of publications
57.14
%
% Q1
42.86
%
% D1
71.43
%
% Leadership
20.00
%
% Female Leadership
2.63
CROWN (2021-2025)
14.89
%
HCP10% (2021-2025)
71.43
%
% Open access
42.86
%
% International Collaboration
3
Highly cited papers / HCP 1% (2021-2025)
0
Publications in high-IF journals with high Altmetric scores
6
Number of Ongoing Projectes (total)
0
International ongoing projects
1
Number of New projects (total)
0
International new projects
0
Number of Active clinical Trials
0
Number of New Clinical Trials
0
Number of Theses
During the year 2025 we have been following our work on metabolic regulation with Cerium oxide NPs (CeO2 NPs), with ionizable lipid nanoparticles (iLNPs) for oligonucleotide deliver, and gold nanoparticles (Au NPs) conjugated with cisplatin for enhanced radio and chemotherapy. With cerium oxide nanoparticles (CeO₂ NPs), we leveraged their ROS-scavenging properties to restore immunosurveillance, preventing death in a peripheral T-cell lymphoma mouse model. Using the same NPs, we also elucidated the causal role of diesel exhaust particles in ventricular arrhythmogenesis and the protective effects of CeO₂ NPs. Regarding ionizable lipid nanoparticles (iLNPs), we completed a unified methodology for producing high-quality NPs capable of encapsulating any oligonucleotide sequence, from siRNA to large plasmids. With gold nanoparticles (Au NPs) conjugated to cisplatin, we developed their application in radiotherapy to consolidate tumor cell DNA damage and prevent repair.
CORE/MISSIONS
- Aging
- Innovative & Advanced Therapies
PROGRAMS
- Robotic Surgery & Simulation
- Woman, Gender & Diversity Perspective in Health Research
TEAM
Group Leader
Víctor Puntes
Researchers
Joan Comenge Farré
PhD Students
Noemi Canalda Batalla, Carolina Vicente Tomàs, Gala Granero Lloria, Ramón Gonzalez Rioja
SELECTED PUBLICATIONS
E Casals, MF Gusta, N Bastus, J Rello, V Puntes
Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections
Microorganisms 13 (4), 952 (2025)
DOI: 10.3390/microorganisms13040952
IF: 4.2
Freddy G. Ganse, Lena M. Ernst, Cristina Rodríguez, Marisol Ruiz-Meana, Javier Inserte, José Martínez-González, Ana M. Briones, Ana Belén García-Redondo, Marta Consegal, Elisabet Miró-Casas, Laia Yáñez-Bisbe, Aitor Pomposo, Marta Prades-Martínez, Ignacio Ferreira-González, Victor Puntes, Begoña Benito & Antonio Rodríguez-Sinovas
Insights into the causal role of diesel exhaust particles in ventricular arrhythmogenesis: protective effects of antioxidant cerium oxide nanoparticles
Particle and Fibre Toxicology, 22, 36 (2025)
DOI: 10.1186/s12989-025-00649-2
IF: 8.2
Nhung H. A. Nguyen, Marlita Marlita, Joana Ramis, Miguel A. Gomez-Gonzalez, Miroslava Rysova, Anna Duarri, Victor F. Puntes & Alena Sevcu
Response of Ocular Bacteria Exposure to Cerium Oxide Nanoparticles in Eye Drop Formulation
Current Microbiology 83:68
DOI: 10.1007/s00284-025-04652-w
IF: 2.6
K Mejía-Carmona, MF Gustà, P Guardia, MC Spadaro, J Arbiol, V Puntes
Size Control of Highly Monodisperse Citrate-Stabilized Magnetite Nanoparticles in Aqueous Media: The Role of Cerium Cation
Chemistry of Materials 37 (19), 7846-7857 (2025)
DOI: 0.1021/acs.chemmater.5c01492
IF: 7.0
SELECTED PROJECTS
CeO2 Nanoparticles for Metabolic Regulation and Treatment of Oxidative stress and Disease. (TRANSCERIA-BIO)
Principal Investigator: Víctor Puntes
Agency: AEI
Funding: 312,700 €
Period: 2024-2028
Improving Brain Arteriovenous Malformation Cure with local Antioncogenic Nanoparticle Embolization
Principal Investigator: Marc Ribó
Agency: Fundació La Caixa
Funding: 201,200 €
Period: 2024-2028
Buscando el camino para la autosuficiencia: preservación corneal con nuevos antioxidantes minerales (nanopartículas de óxido de cerio). Proyecto PRE-CO-CE
Principal Investigator: Anna Vilarodona
Agency: Fundación Mutua Madrileña
Funding: 110,000 €
Period: 2024-2027
2-in-1 Nanogold for a Synergistic Enhancement of Radiotherapy and Chemotherapy
Principal Investigator: Víctor Puntes
Agency: AECC
Funding: 149,700 €
Period: 2024-2027
A new formulation of cerium oxide nanoparticles as adjuvant for retinal anti-angiogenesis therapy
Principal Investigator: Víctor Puntes
Agency: AGAUR
Funding: 150,000 €
Period: 2024-2025
PATENTS
Hybrid ceria and gold nanoparticles for use in simultaneous medical diagnosis and radio-protection and theragnostic agent comprising them
Priority Number: EP2025/067167
Priority Date: 26/12/2025
Applicants: VHIR/ICN2/ICREA
DISSEMINATION ACTIVITIES
Nit de la recerca
Place: Casa Golferichs (Barcelona)
Date: 26/09/2025
Brief: Victor Puntes and Eduardo Green performed a show which combines science divulgation, live music and projection of science images.
Colonies per la ciència - AECC
Place: Castell Fluvià -Santa Maria de Palautordera
Date: 16/07/2025
Brief: Gala Granero (PhD student from our group) participated in a workshop for kids where they create gel capsules to mimic drug delivery systems
Engaging Publics for Responsible Nanoscience & Nanotechnology (EPReN2)
Place: Centre Cívi Pere Quart
Date: Monthly meetings
Brief: Ramon González, Joan Comenge and Víctor Puntes from our group participated in several open disccussions with general audience about nanomedicine, research, involvement of society in scientific advances, etc. in the mark of an European Project.
