García-Rodríguez, Paula; Ramiro, Laura; Simats, Alba; Ma, Feifei; Rosell, Anna; Montaner, Joan.
Identifying New Blood Biomarkers of Neuroplasticity Associated with Rehabilitation Outcomes after Stroke.
Sci Rep. 2025 Oct 30;15(1):38047
DOI: 10.1038/s41598-025-21936-0
IF: 3.9
RESEARCH GROUPS
Neurovascular Diseases
23
Number of publications
69.57
%
% Q1
26.09
%
% D1
39.13
%
% Leadership
55.56
%
% Female Leadership
2.81
CROWN (2021-2025)
28.15
%
HCP10% (2021-2025)
78.26
%
% Open access
56.52
%
% International Collaboration
9
Highly cited papers / HCP 1% (2021-2025)
5
Publications in high-IF journals with high Altmetric scores
11
Number of Ongoing Projectes (total)
0
International ongoing projects
5
Number of New projects (total)
0
International new projects
5
Number of Active clinical Trials
1
Number of New Clinical Trials
3
Number of Theses
At the Neurovascular Research Laboratory, we have led a range of research projects and industry collaborations focused on stroke, vascular dementia, and Alzheimer’s disease. By expanding our patient cohorts and conducting multiple preclinical studies, we have worked to identify novel biomarkers for stroke recovery and for the diagnosis of other neurological conditions. In addition, we have evaluated new therapeutic compounds in preclinical stroke models, aiming to promote neuroprotection and enhance tissue repair. We have also strengthened collaborations with biotech and pharmaceutical companies, contributing to the preclinical development of innovative treatments for both stroke and Alzheimer’s disease.
CORE/MISSIONS
- Aging
- Environmental & Public Health
- Innovative & Advanced Therapies
PROGRAMS
TEAM
Group Leader
Anna Rosell Novel
Principal Investigator (PI)
Anna Rosell Novel, Mar Hernández Guillamon, Pilar Delgado Martínez
Researchers
Olga Maisterra Santos, Antonio Palasí Franco, Mariateresa Buongiorno, Alejandro Ballvé Martín, Darly Milena Giraldo Salazar, Fernando Ruiz Esteve
PhD Students
Paula García Rodríguez, Marta Klimczak, Berta Páez Montserrat, Fu Chen, Itsasne de la Torre Sánchez, Laia Fernández Resano, Liubovi Sopco, Marina Pérez González, Nicolás García Rodríguez
Lab Technicians
Anna Penalba Morenilla, Miguel García Gabilondo, Kerrie Adrián Campbell
SELECTED PUBLICATIONS
García-Rodríguez, Paula; Ramiro, Laura; Simats, Alba; Ma, Feifei; Rosell, Anna; Montaner, Joan. Journal of Cererbal Blood Flow and Metabolism.
Combination of Alpha-1 antitrypsin (A1AT) and anti-TNFα as a neuroprotective strategy in the early stages after ischemic stroke.
J Cereb Blood Flow Metab. 2025 Oct;45(10):1993-2003
DOI: 10.1177/0271678X251340234
IF: 4.5
Santamarina E, Abraira L, Campos-Fernández D, Quintana M, Fonseca E, López-Maza S, Lallana S, Penalba A, Rosell A, Valor-Blanquer J, Sanz C, Toledo M.
Extracellular vesicle proteomics identifies novel blood biomarkers for the early diagnosis of status epilepticus. Epilepsia.
Epilepsia. Epub 2025 Nov 9.
DOI: 10.1111/epi.70008
IF: 6.6
Hernández-Fernández F, Martínez-Fernández I, Barbella-Aponte R, Vilar IF, Ayo-Martín O, García-García J, Collado R, Andrés A, Hernández-Guillamón M, Pena Pardo FJ, Barrena C, de la Fuente M, Serrano-Heras G, Melero M, Setién EL, López L, Segura T.
Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co-pathology.
Ann Clin Transl Neurol. 2025 Jan;12(1):235-241
DOI: 10.1002/acn3.52278
IF: 3.9
Buongiorno M, Sánchez-Benavides G, Caruana G, Elias-Mas A, Artero C, Cullell N, Delgado P, Giraldo DM, Marzal-Espí C, Grau-Rivera O, de la Sierra A, Delgado-Sanchez A, Ray NJ, Krupinski J.
Abnormal sleep blood pressure patterns are associated with the diffusion tensor imaging along the perivascular space index in cognitively impaired individuals.
Front Aging Neurosci. 2025 Aug 29;17:1578270
DOI: 10.3389/fnagi.2025.1578270
IF: 4.5
SELECTED PROJECTS
RD24/0009/0020: Redes Temáticas RICORS. RICORS-ICTUS.
Principal Investigator: Anna Rosell
Agency: ISCIII-Fondo de Investigación Sanitaria.
Funding: 216,832 €
Period: 2025-2027
AC22/00051: ELAPSE-ND: European-Latin American and Caribbean collaborative project on personalized medicine for neurological disorders.
Principal Investigator: Mar Hernández
Agency: ISCIII-EU-LAC Joint Call
Funding: 174,850 €
Period: 2023-2025
PI22/01055: Testing the endovascular route for improved neuroprotection and neurorepair in stroke recovery.
Principal Investigator: Anna Rosell
Agency: ISCIII-Fondo de Investigación Sanitaria.
Funding: 141,570 €
Period: 2023-2025
PI23/00082: Role of MFGE8 as potential biomarker and therapeutic target in cerebral amyloid angiopathy.
Principal Investigator: Mar Hernandez
Agency: ISCIII-Fondo de Investigación Sanitaria.
Funding: 208,750 €
Period: 2024-2026
202333-30-31: Endovascular Delivery of therapeutic nanocarriers for stroke recovery (End-Stroke).
Principal Investigator: Anna Rosell
Agency: Fundació La Marató
Funding: 173,750 €
Period: 05/2024-05/2027
PATENTS
Therapeutic Intra-Arterial Route for Acute stroke
Priority Number: EP25383155
Priority Date: 24/10/2025
Applicants: Vall d’Hebron Research Institute and Fundación para la gestión de la Investigación en salud de Sevilla
DISSEMINATION ACTIVITIES
Jornada Alzheimer 2025
Place: Vall d'Hebron Campus
Date: 17/11/2025
Brief: Organization and participation in the first Alzheimer’s Day at the campus, involving researchers, clinicians, patients, families, and associations.
International Day of Women and Girls in Science 2025.
Place: Vall d'Hebron Research Institute
Date: 11/02/2025
Brief: Communication pills for schools and lab visits.
VHIR Open Day 2025
Place: Vall d'Hebron Research Institute
Date: 15/03/2025
Brief: Participation through an outreach presentation showcasing the group’s research activities.
Educational Talks and Laboratory Visits
Place: Vall d'Hebron Research Institute
Date: 2025
Brief: Several educational talks and Laboratory visits on brain health, scientific projects, women in science or stroke awareness among citizens, students, volunteers or donors.
