Santamarina E, Abraira L, Campos-Fernández D, Quintana M, Fonseca E, López-Maza S, Lallana S, Penalba A, Rosell A, Valor-Blanque J, Sanz C, Toledo M.
Extracellular vesicle proteomics identifies novel blood biomarkers for the early diagnosis of status epilepticus
Epilepsia. 2026 Mar;67(3):1469-1482.
DOI: 10.1111/epi.70008
IF: 6.6
RESEARCH GROUPS
Research group on Status Epilepticus and Acute Seizures
11
Number of publications
36.36
%
% Q1
9.09
%
% D1
81.82
%
% Leadership
0.00
%
% Female Leadership
1.48
CROWN (2021-2025)
18.52
%
HCP10% (2021-2025)
45.45
%
% Open access
18.18
%
% International Collaboration
2
Highly cited papers / HCP 1% (2021-2025)
0
Publications in high-IF journals with high Altmetric scores
4
Number of Ongoing Projectes (total)
0
International ongoing projects
0
Number of New projects (total)
0
International new projects
16
Number of Active clinical Trials
6
Number of New Clinical Trials
2
Number of Theses
Our research group has made significant progress in using biomarkers to improve epilepsy diagnosis and prediction across clinical settings. Novel blood biomarkers have been identified to predict epilepsy after stroke, as well as to enable faster diagnosis of status epilepticus. In addition, electroencephalogram (EEG) and neuroimaging biomarkers have been developed to predict cognitive decline and disease progression, along with markers of neuronal damage in temporal lobe epilepsy. These advances integrate biological, electrophysiological, and imaging data, improving clinical management. Finally, collaborations with technology companies have been established to apply artificial intelligence to EEG and identify new biomarkers for epilepsy diagnosis. Furthermore, our group maintains a prominent position in recruiting subjects for international clinical trials related to epilepsy.
CORE/MISSIONS
PROGRAMS
TEAM
Group Leader
Estevo Santamarina Pérez
Principal Investigator (PI)
Manuel Toledo Argany, Laura Abraira del Fresno, Elena Fonseca Hernández
Researchers
Daniel Campos Fernández, María Garcés Pellejero, Samuel López Maza
SELECTED PUBLICATIONS
Fonseca E, Thomson A, Alonso M, Contreras Ó, de la Cruz W, Garcés-Pellejero M, Bellido-Castillo E, Espinosa-Jovel C, Velásquez A, de Font-Reaulx E, Flores C, Mayor-Romero LC, Martínez P, Rodríguez-Osorio X, Juiz Á, Carreño M, Conde E, Olivera M, Barreto-Acevedo E, Rodríguez O, Rodríguez-Uranga J, Maestro I, Falip M, Hernández G, Serratosa JM, Cordero E, Quintana M, López-Maza S, Campos-Fernández D, Abraira L, Santamarina E, Wiebe S, Toledo M.
Spanish translation, adaptation, and validation of the Epilepsy Surgery Satisfaction Questionnaire-19
Epilepsia. 2026 Jan;67(1):315-327
DOI: 10.1111/epi.18631
IF: 6.6
Grávalos M, Mayol J, Fonseca E, Quintana M, López-Maza S, Campos-Fernández D, Abraira L, Santamarina E, Toledo M.
The Medical Burden of Drug-Resistant Epilepsy in an Outpatient Clinic of a Tertiary Hospital: A Prospective Study Based on Real-World Evidence
Eur J Neurol. 2025 Nov;32(11):e70407
DOI: 10.1111/ene.70407
IF: 3.9
Bellido-Castillo E, Kaestner EJ, Bearden DJ, McDonald CR, Toledo M, Fonseca E
Can memory mapping via stereo-electroencephalography stimulation predict post-operative memory outcomes? A case report
J Neurol. 2025 Aug 25;272(9):591
DOI: 10.1007/s00415-025-13307-6
IF: 4.6
Schubert KM, Zieglgänsberger D, Bicciato G, Abraira L, Santamarina E, Álvarez-Sabín J, Ferreira-Atuesta C, Katan M, Sinka L, Terziev R, Deligas N, Erdélyi-Canavese B, Felbecker A, Siebel P, Winklehner M, von Oertzen TJ, Wagner JN, Gigli GL, Nilo A, Janes F, Merlino G, Valente M, Zafra-Sierra MP, Mayor-Romero LC, Conrad J, Evers S, Alet M, Fukuma K, Ihara M, Landau B, Lochner P, Roell F, Brigo F, Bentes C, Peralta AR, Pinho E Melo T, Keezer MR, Duncan JS, Sander JW, Tettenborn B, Koepp MJ, Galovic M
Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality
Stroke. 2025 Jul;56(7):1748-1757.
DOI: 10.1161/STROKEAHA.124.050045
IF: 8.9
SELECTED PROJECTS
Biomarcadores séricos predictivos de epilepsia tras una hemorragia cerebral aguda
Principal Investigator: Laura Abraira Del Fresno
Agency: Instituto de Salud Carlos III
Funding: 102,500 €
Period: 2025-2027
Detección precoz y estrategias preventivas del deterioro cognitivo en pacientes con epilepsia de reciente diagnóstico
Principal Investigator: Elena Fonseca Hernández
Agency: Instituto de Salud Carlos III
Funding: 196,250 €
Period: 2025-2027
Evaluación multimodal mediante biomarcadores para la predicción y manejo personalizado de la epilepsia secundaria a subaracnoidea aneurismática
Principal Investigator: Estevo Santamarina Pérez
Agency: Fundació Institut de Recerca HUVH
Funding: 117,000 €
Period: 2023-2025
Caracterització dels mecanismes fisiopatològics i clínics de l'epilèpsia d'inici tardà i etiologia desconeguda
Principal Investigator: Laura Abraira Del Fresno
Agency: Fundació Institut de Recerca HUVH
Funding: 35,000 €
Period: 2024-2025
PATENTS
DISSEMINATION ACTIVITIES
International Day Against Epilepsy
Place: Hospital Universitari Vall d'Hebron
Date: 10/02/2025
Brief: Our group organized this activity in the International Day Against Epilepsy at Vall d'Hebron Hospital in collaboration with the Síndrome de Dravet Fundation, promoting public awareness, education, and collaboration between healthcare professional, patients, and families.
